Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population
Joint Authors
Khatiwada, Saroj
KC, Rajendra
Lamsal, Madhab
Deo Mehta, Kishun
Pandey, Pratikshya
Majhi, Shankhar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
To assess cardiovascular risk factors in Nepalese population with subclinical hypothyroidism as compared to age and sex matched controls.
Materials and Methods.
A case control study was conducted among 200 subjects (100 subclinical hypothyroid and 100 euthyroid) at B.P.
Koirala Institute of Health Sciences, Dharan, Nepal.
Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken.
Blood samples were assayed for serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and high sensitivity C reactive protein (hs-CRP).
Results.
Subclinical hypothyroid patients had significantly higher diastolic BP, total cholesterol, LDL cholesterol, and hs-CRP than controls.
The odds ratio of having hypercholesterolemia (>200 mg/dL), low HDL cholesterol (<40 mg/dL), undesirable LDL-cholesterol (>100 mg/dL), high hs-CRP (>1 mg/L), and high diastolic BP (>80 mmHg) and being overweight (BMI ≥ 23 Kg/m2) in subclinical hypothyroidism was 2.29 (95% CI; 1.2–4.38, p=0.011), 1.73 (95% CI; 0.82–3.62, p=0.141), 3.04 (95% CI; 1.66–5.56, p<0.001), 2.02 (95% CI; 1.12–3.64, p=0.018), 3.35 (95% CI; 1.72–6.55, p<0.001), and 0.9 (95% CI; 0.48–1.67, p=0.753), respectively, as compared to controls.
Conclusion.
Subclinical hypothyroid patients are associated with higher risk for cardiovascular disease than euthyroid subjects.
American Psychological Association (APA)
KC, Rajendra& Khatiwada, Saroj& Deo Mehta, Kishun& Pandey, Pratikshya& Lamsal, Madhab& Majhi, Shankhar. 2015. Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population. Journal of Thyroid Research،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1070423
Modern Language Association (MLA)
KC, Rajendra…[et al.]. Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population. Journal of Thyroid Research No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1070423
American Medical Association (AMA)
KC, Rajendra& Khatiwada, Saroj& Deo Mehta, Kishun& Pandey, Pratikshya& Lamsal, Madhab& Majhi, Shankhar. Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population. Journal of Thyroid Research. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1070423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070423