Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments
Joint Authors
Mohamed, Ateesha F.
González, Juan Marcos
Fairchild, Angelyn
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The aims of this study were to assess patients’ preferences to wait or start systemic treatment and understand how patients would make tradeoffs between certain severe adverse events (AEs) and additional months of progression-free survival (PFS).
Materials and Methods.
Adults in France, Germany, and Spain with a diagnosis of DTC and who have had at least one RAI treatment completed a direct-elicitation question and a discrete-choice experiment (DCE) online.
The direct-elicitation question asked respondents whether they would opt out of treatment when their tumor is RAI-R.
In the DCE, respondents chose between 12 pairs of hypothetical RAI-R DTC treatment profiles.
Profiles were defined by magnitudes of efficacy (PFS) and safety (severe hand-foot skin reaction [HFSR], severe proteinuria, and severe hypertension).
A main-effects random-parameters logit model was estimated.
Results.
134 patients completed the survey.
Most patients (86.6%) opted for treatment rather than “wait and see” decision.
Patients placed a greater weight on the risk of severe hypertension than the risk of proteinuria and HFSR.
Conclusions.
DTC patients showed preference toward treatment for RAI-R DTC over watchful waiting.
Patients’ concerns about the risk of severe hypertension appeared to have had a greater effect on patients’ choice than severe proteinuria or HFSR.
American Psychological Association (APA)
Mohamed, Ateesha F.& González, Juan Marcos& Fairchild, Angelyn. 2015. Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments. Journal of Thyroid Research،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1070424
Modern Language Association (MLA)
Mohamed, Ateesha F.…[et al.]. Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments. Journal of Thyroid Research No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1070424
American Medical Association (AMA)
Mohamed, Ateesha F.& González, Juan Marcos& Fairchild, Angelyn. Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments. Journal of Thyroid Research. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1070424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070424