Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective
Joint Authors
Sharma, Neera
Sharma, Lokesh Kumar
Dutta, Deep
Gadpayle, Adesh Kisanji
Anand, Atul
Gaurav, Kumar
Mukherjee, Sabyasachi
Bansal, Rahul
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Predictors of thyroid dysfunction in HIV are not well determined.
This study aimed to determine the prevalence and predictors of thyroid dysfunction in HIV infected Indians.
Methods.
Consecutive HIV patients, 18–70 years of age, without any severe comorbid state, having at least 1-year follow-up at the antiretroviral therapy clinic, underwent clinical assessment and hormone assays.
Results.
From initially screened 527 patients, 359 patients ( 61.44 ± 39.42 months’ disease duration), having good immune function [CD4 count >200 cell/mm3: 90.25%; highly active antiretroviral therapy (HAART): 88.58%], were analyzed.
Subclinical hypothyroidism (ScH) was the commonest thyroid dysfunction (14.76%) followed by sick euthyroid syndrome (SES) (5.29%) and isolated low TSH (3.1%).
Anti-TPO antibody (TPOAb) was positive in 3.90%.
Baseline CD4 count had inverse correlation with TPOAb after adjusting for age and body mass index.
Stepwise linear regression revealed baseline CD4 count, TPOAb, and tuberculosis to be best predictors of ScH after adjusting for age, weight, duration of HIV, and history of opportunistic fungal and viral infections.
Conclusion.
Burden of thyroid dysfunction in chronic HIV infection with stable immune function is lower compared to pre-HAART era.
Thyroid dysfunction is primarily of nonautoimmune origin, predominantly ScH.
Severe immunodeficiency at disease onset, TPOAb positivity, and tuberculosis were best predictors of ScH.
American Psychological Association (APA)
Sharma, Neera& Sharma, Lokesh Kumar& Dutta, Deep& Gadpayle, Adesh Kisanji& Anand, Atul& Gaurav, Kumar…[et al.]. 2015. Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective. Journal of Thyroid Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070426
Modern Language Association (MLA)
Sharma, Neera…[et al.]. Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective. Journal of Thyroid Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1070426
American Medical Association (AMA)
Sharma, Neera& Sharma, Lokesh Kumar& Dutta, Deep& Gadpayle, Adesh Kisanji& Anand, Atul& Gaurav, Kumar…[et al.]. Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective. Journal of Thyroid Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070426