Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT
Joint Authors
Sikjaer, Tanja
Moser, Emil
Mosekilde, Leif
Rejnmark, Lars
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Studies on bone effects of long-term substitution therapy with levothyroxine (LT4) have shown discrepant results.
Previous studies have, however, not evaluated volumetric bone mineral densities (vBMD), bone structure, and strength using high resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA).
Using a cross-sectional design, we aimed to determine whether BMD, structure, and strength are affected in hypothyroid patients on LT4 substitution therapy.
Methods.
We compared 49 patients with well-substituted hypothyroidism with 49 age- and gender-matched population based controls.
Areal BMD was assessed by DXA, vBMD and bone geometry by HR-pQCT, and bone strength by FEA.
Results.
Patients had been thyroidectomized due to thyroid cancer (10%) and nontoxic (33%) or toxic goiter (57%).
82% were women.
TSH levels did not differ between groups, but patients had significantly higher levels of T4 (p<0.001) and lower levels of T3 (p<0.01).
Compared to controls, patients had higher levels of magnesium (p<0.05), whereas ionized calcium and PTH were lower (p<0.05).
Bone scans did not reveal any differences in BMD, bone geometry, or strength.
Conclusion.
If patients with hypothyroidism are well-substituted with LT4, the disease does not affect bone indices to any major degree.
American Psychological Association (APA)
Moser, Emil& Sikjaer, Tanja& Mosekilde, Leif& Rejnmark, Lars. 2015. Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT. Journal of Thyroid Research،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070429
Modern Language Association (MLA)
Moser, Emil…[et al.]. Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT. Journal of Thyroid Research No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1070429
American Medical Association (AMA)
Moser, Emil& Sikjaer, Tanja& Mosekilde, Leif& Rejnmark, Lars. Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT. Journal of Thyroid Research. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070429