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Risk-Adjusted Analysis of Relevant Outcome Drivers for Patients after More Than Two Kidney Transplants
Joint Authors
Lehner, Frank
Klempnauer, Juergen
Schrem, Harald
Vondran, F. W. R.
Kousoulas, Lampros
Syryca, Paulina
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Renal transplantation is the treatment of choice for patients suffering end-stage renal disease, but as the long-term renal allograft survival is limited, most transplant recipients will face graft loss and will be considered for a retransplantation.
The goal of this study was to evaluate the patient and graft survival of the 61 renal transplant recipients after second or subsequent renal transplantation, transplanted in our institution between 1990 and 2010, and to identify risk factors related to inferior outcomes.
Actuarial patient survival was 98.3%, 94.8%, and 88.2% after one, three, and five years, respectively.
Actuarial graft survival was 86.8%, 80%, and 78.1% after one, three, and five years, respectively.
Risk-adjusted analysis revealed that only age at the time of last transplantation had a significant influence on patient survival, whereas graft survival was influenced by multiple immunological and surgical factors, such as the number of HLA mismatches, the type of immunosuppression, the number of surgical complications, need of reoperation, primary graft nonfunction, and acute rejection episodes.
In conclusion, third and subsequent renal transplantation constitute a valid therapeutic option, but inferior outcomes should be expected among elderly patients, hyperimmunized recipients, and recipients with multiple operations at the site of last renal transplantation.
American Psychological Association (APA)
Kousoulas, Lampros& Vondran, F. W. R.& Syryca, Paulina& Klempnauer, Juergen& Schrem, Harald& Lehner, Frank. 2015. Risk-Adjusted Analysis of Relevant Outcome Drivers for Patients after More Than Two Kidney Transplants. Journal of Transplantation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070438
Modern Language Association (MLA)
Kousoulas, Lampros…[et al.]. Risk-Adjusted Analysis of Relevant Outcome Drivers for Patients after More Than Two Kidney Transplants. Journal of Transplantation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1070438
American Medical Association (AMA)
Kousoulas, Lampros& Vondran, F. W. R.& Syryca, Paulina& Klempnauer, Juergen& Schrem, Harald& Lehner, Frank. Risk-Adjusted Analysis of Relevant Outcome Drivers for Patients after More Than Two Kidney Transplants. Journal of Transplantation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1070438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070438