The Benefit of Sirolimus Maintenance Immunosuppression and Rabbit Antithymocyte Globulin Induction in Liver Transplant Recipients That Develop Acute Kidney Injury in the Early Postoperative Period
Joint Authors
Duhart, Benjamin T.
Ally, Winston A.
Krauss, Amy G.
Hudson, Joanna Q.
Eason, James D.
Rao, Vinaya
Vanatta, Jason M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Published data are limited describing renal outcomes in orthotopic liver transplant (OLT) recipients prescribed sirolimus (SRL) maintenance immunosuppression (MIS) and rabbit antithymocyte globulin (rATG) induction.
We investigated whether SRL MIS and rATG induction facilitated recovery of acute kidney injury in the early postoperative period.
This retrospective descriptive study screened 308 consecutive OLTs performed between 2006 and 2009.
All patients received rATG induction with steroid avoidance.
MIS consisted of SRL or TAC with mycophenolate mofetil.
A total of 197 patients were included: 168 (85%) received TAC and 29 (15%) received SRL for a median of 365 days.
Demographics were similar between groups except for a higher incidence of pretransplant renal dysfunction in the SRL recipients (SRL 59% versus TAC 21%; P < 0.05 ).
The eGFR was significantly ( P < 0.05 ) higher for all time points in the TAC group with the exception of month 2.
However, improvement in eGFR was significantly ( P < 0.05 ) greater in the SRL group postoperatively.
Our study suggests that rATG induction and SRL maintenance immunosuppression facilitate renal recovery for liver transplant recipients that develop acute kidney injury in the early postoperative period.
American Psychological Association (APA)
Duhart, Benjamin T.& Ally, Winston A.& Krauss, Amy G.& Hudson, Joanna Q.& Eason, James D.& Rao, Vinaya…[et al.]. 2015. The Benefit of Sirolimus Maintenance Immunosuppression and Rabbit Antithymocyte Globulin Induction in Liver Transplant Recipients That Develop Acute Kidney Injury in the Early Postoperative Period. Journal of Transplantation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1070444
Modern Language Association (MLA)
Duhart, Benjamin T.…[et al.]. The Benefit of Sirolimus Maintenance Immunosuppression and Rabbit Antithymocyte Globulin Induction in Liver Transplant Recipients That Develop Acute Kidney Injury in the Early Postoperative Period. Journal of Transplantation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1070444
American Medical Association (AMA)
Duhart, Benjamin T.& Ally, Winston A.& Krauss, Amy G.& Hudson, Joanna Q.& Eason, James D.& Rao, Vinaya…[et al.]. The Benefit of Sirolimus Maintenance Immunosuppression and Rabbit Antithymocyte Globulin Induction in Liver Transplant Recipients That Develop Acute Kidney Injury in the Early Postoperative Period. Journal of Transplantation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1070444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070444