Binding of CXCL8IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
Joint Authors
Kurdowska, A.
Brzostek, Anna
Torzewska, Agnieszka
Krupa, Agnieszka
Dziadek, Bozena R.
Kepka, Ewa
Wojciechowska, Dominika
Baughman, Robert P.
Griffith, David
Dziadek, Jaroslaw
Fol, Marek
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Interleukin-8 (IL-8) has been implicated in the pathogenesis of several human respiratory diseases, including tuberculosis (TB).
Importantly and in direct relevance to the objectives of this report quite a few findings suggest that the presence of IL-8 may be beneficial for the host.
IL-8 may aid with mounting an adequate response during infection with Mycobacterium tuberculosis (M.
tb); however, the underlying mechanism remains largely unknown.
The major goal of our study was to investigate the contribution of IL-8 to the inflammatory processes that are typically elicited in patients with TB.
We have shown for the first time that IL-8 can directly bind to tubercle bacilli.
We have also demonstrated that association of IL-8 with M.
tb molecules leads to the augmentation of the ability of leukocytes (neutrophils and macrophages) to phagocyte and kill these bacilli.
In addition, we have shown that significant amount of IL-8 present in the blood of TB patients associates with erythrocytes.
Finally, we have noted that IL-8 is the major chemokine responsible for recruiting T lymphocytes (CD3+, CD4+, and CD8+ T cells).
In summary, our data suggest that the association of IL-8 with M.
tb molecules may modify and possibly enhance the innate immune response in patients with TB.
American Psychological Association (APA)
Krupa, Agnieszka& Fol, Marek& Dziadek, Bozena R.& Kepka, Ewa& Wojciechowska, Dominika& Brzostek, Anna…[et al.]. 2015. Binding of CXCL8IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072121
Modern Language Association (MLA)
Krupa, Agnieszka…[et al.]. Binding of CXCL8IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072121
American Medical Association (AMA)
Krupa, Agnieszka& Fol, Marek& Dziadek, Bozena R.& Kepka, Ewa& Wojciechowska, Dominika& Brzostek, Anna…[et al.]. Binding of CXCL8IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072121