![](/images/graphics-bg.png)
Impaired Fracture Healing after Hemorrhagic Shock
Joint Authors
Kobbe, Philipp
Lichte, Philipp
Pape, Hans-Christoph
Pfeifer, Roman
Pufe, T.
Tohidnezhad, Mersedeh
Beckmann, Rainer
Kadyrov, Mamed
Campbell, Graeme C.
Bergmann, Christian
Glüer, Christian C.
Fischer, Horst
Hildebrand, Frank
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Impaired fracture healing can occur in severely injured patients with hemorrhagic shock due to decreased soft tissue perfusion after trauma.
We investigated the effects of fracture healing in a standardized pressure controlled hemorrhagic shock model in mice, to test the hypothesis that bleeding is relevant in the bone healing response.
Male C57/BL6 mice were subjected to a closed femoral shaft fracture stabilized by intramedullary nailing.
One group was additionally subjected to pressure controlled hemorrhagic shock (HS, mean arterial pressure (MAP) of 35 mmHg for 90 minutes).
Serum cytokines (IL-6, KC, MCP-1, and TNF- α ) were analyzed 6 hours after shock.
Fracture healing was assessed 21 days after fracture.
Hemorrhagic shock is associated with a significant increase in serum inflammatory cytokines in the early phase.
Histologic analysis demonstrated a significantly decreased number of osteoclasts, a decrease in bone quality, and more cartilage islands after hemorrhagic shock.
μCT analysis showed a trend towards decreased bone tissue mineral density in the HS group.
Mechanical testing revealed no difference in tensile failure.
Our results suggest a delay in fracture healing after hemorrhagic shock.
This may be due to significantly diminished osteoclast recruitment.
The exact mechanisms should be studied further, particularly during earlier stages of fracture healing.
American Psychological Association (APA)
Lichte, Philipp& Kobbe, Philipp& Pfeifer, Roman& Campbell, Graeme C.& Beckmann, Rainer& Tohidnezhad, Mersedeh…[et al.]. 2015. Impaired Fracture Healing after Hemorrhagic Shock. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072129
Modern Language Association (MLA)
Lichte, Philipp…[et al.]. Impaired Fracture Healing after Hemorrhagic Shock. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072129
American Medical Association (AMA)
Lichte, Philipp& Kobbe, Philipp& Pfeifer, Roman& Campbell, Graeme C.& Beckmann, Rainer& Tohidnezhad, Mersedeh…[et al.]. Impaired Fracture Healing after Hemorrhagic Shock. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072129