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Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment
Joint Authors
Kumawat, Ashok Kumar
Tysk, Curt
Hultgren Hörnquist, Elisabeth
Bohr, Johan
Hultgren, Olof
Günaltay, Sezin
Nyhlin, Nils
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea.
Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology.
We compared gene and protein expressions of different immune cell attracting chemokines and their receptors in colon biopsies from MC patients in active disease or histopathological remission (CC/LC-HR) with controls, using qRT-PCR and Luminex, respectively.
CC and LC patients with active disease demonstrated a mixed chemokine profile with significantly enhanced gene and/or protein expressions of the chemokines CCL2, CCL3, CCL4, CCL5, CCL7, CCL22, CXCL8, CXCL9, CXCL10, CXCL11, and CX3CL1 and the receptors CCR2, CCR3, CCR4, CXCR1, CXCR2, and CX3CR1.
Enhanced chemokine/chemokine receptor gene and protein levels in LC-HR patients were similar to LC patients, whereas CC-HR patients demonstrated almost normalized levels.
These findings expand the current understanding of the involvement of various immune cells in MC immunopathology and endorse chemokines as potential diagnostic markers as well as therapeutic candidates.
Moreover, this study further supports the hypothesis that CC and LC are two different entities due to differences in their immunoregulatory responses.
American Psychological Association (APA)
Günaltay, Sezin& Kumawat, Ashok Kumar& Nyhlin, Nils& Bohr, Johan& Tysk, Curt& Hultgren, Olof…[et al.]. 2015. Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072132
Modern Language Association (MLA)
Günaltay, Sezin…[et al.]. Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072132
American Medical Association (AMA)
Günaltay, Sezin& Kumawat, Ashok Kumar& Nyhlin, Nils& Bohr, Johan& Tysk, Curt& Hultgren, Olof…[et al.]. Enhanced Levels of Chemokines and Their Receptors in the Colon of Microscopic Colitis Patients Indicate Mixed Immune Cell Recruitment. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072132