Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer’s Disease
Joint Authors
Kesavalu, Lakshmyya
Singhrao, Sim K.
Harding, Alice
Poole, Sophie
Crean, StJohn
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Periodontal disease (PD) and Alzheimer’s disease (AD) are inflammatory conditions affecting the global adult population.
In the pathogenesis of PD, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and alveolar bone resorption around the teeth.
In health, junctional epithelium seals the gingiva to the tooth enamel, thus preventing bacteria from entering the gingivae.
Chronic PD involves major pathogens (Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia) which have an immune armoury that can circumvent host’s immune surveillance to create and maintain an inflammatory mediator rich and toxic environment to grow and survive.
The neurodegenerative condition, AD, is characterised by poor memory and specific hallmark proteins; periodontal pathogens are increasingly being linked with this dementing condition.
It is therefore becoming important to understand associations of periodontitis with relevance to late-onset AD.
The aim of this review is to discuss the relevance of finding the keystone periodontal pathogen P.
gingivalis in AD brains and its plausible contribution to the aetiological hypothesis of this dementing condition.
American Psychological Association (APA)
Singhrao, Sim K.& Harding, Alice& Poole, Sophie& Kesavalu, Lakshmyya& Crean, StJohn. 2015. Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer’s Disease. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072134
Modern Language Association (MLA)
Singhrao, Sim K.…[et al.]. Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer’s Disease. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072134
American Medical Association (AMA)
Singhrao, Sim K.& Harding, Alice& Poole, Sophie& Kesavalu, Lakshmyya& Crean, StJohn. Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer’s Disease. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072134