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iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants
Joint Authors
Cassini-Vieira, Puebla
Araújo, Fernanda Assis
da Costa Dias, Filipi Leles
Russo, Remo Castro
Barcelos, Luciola Silva
Teixeira, Mauro Martins
Andrade, Silvia Passos
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is considerable interest in implantation techniques and scaffolds for tissue engineering and, for safety and biocompatibility reasons, inflammation, angiogenesis, and fibrosis need to be determined.
The contribution of inducible nitric oxide synthase (iNOS) in the regulation of the foreign body reaction induced by subcutaneous implantation of a synthetic matrix was never investigated.
Here, we examined the role of iNOS in angiogenesis, inflammation, and collagen deposition induced by polyether-polyurethane synthetic implants, using mice with targeted disruption of the iNOS gene (iNOS−/−) and wild-type (WT) mice.
The hemoglobin content and number of vessels were decreased in the implants of iNOS−/− mice compared to WT mice 14 days after implantation.
VEGF levels were also reduced in the implants of iNOS−/− mice.
In contrast, the iNOS−/− implants exhibited an increased neutrophil and macrophage infiltration.
However, no alterations were observed in levels of CXCL1 and CCL2, chemokines related to neutrophil and macrophage migration, respectively.
Furthermore, the implants of iNOS−/− mice showed boosted collagen deposition.
These data suggest that iNOS activity controls inflammation, angiogenesis, and fibrogenesis in polyether-polyurethane synthetic implants and that lack of iNOS expression increases foreign body reaction to implants in mice.
American Psychological Association (APA)
Cassini-Vieira, Puebla& Araújo, Fernanda Assis& da Costa Dias, Filipi Leles& Russo, Remo Castro& Andrade, Silvia Passos& Teixeira, Mauro Martins…[et al.]. 2015. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072139
Modern Language Association (MLA)
Cassini-Vieira, Puebla…[et al.]. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072139
American Medical Association (AMA)
Cassini-Vieira, Puebla& Araújo, Fernanda Assis& da Costa Dias, Filipi Leles& Russo, Remo Castro& Andrade, Silvia Passos& Teixeira, Mauro Martins…[et al.]. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072139