![](/images/graphics-bg.png)
MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes
Joint Authors
Garlanda, Cecilia
Renzi, Tiziana Ada
Rubino, Marcello
Gornati, Laura
Locati, Massimo
Curtale, Graziella
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A proper regulation of the innate immune response is fundamental to keep the immune system in check and avoid a chronic status of inflammation.
As they act as negative modulators of TLR signaling pathways, miRNAs have been recently involved in the control of the inflammatory response.
However, their role in the context of endotoxin tolerance is just beginning to be explored.
We here show that miR-146b is upregulated in human monocytes tolerized by LPS, IL-10, or TGFβ priming and demonstrate that its transcription is driven by STAT3 and RUNX3, key factors downstream of IL-10 and TGFβ signaling.
Our study also found that IFNγ, known to revert LPS tolerant state, inhibits miR-146b expression.
Finally, we provide evidence that miR-146b levels have a profound effect on the tolerant state, thus candidating miR-146b as a molecular mediator of endotoxin tolerance.
American Psychological Association (APA)
Renzi, Tiziana Ada& Rubino, Marcello& Gornati, Laura& Garlanda, Cecilia& Locati, Massimo& Curtale, Graziella. 2015. MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072152
Modern Language Association (MLA)
Renzi, Tiziana Ada…[et al.]. MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072152
American Medical Association (AMA)
Renzi, Tiziana Ada& Rubino, Marcello& Gornati, Laura& Garlanda, Cecilia& Locati, Massimo& Curtale, Graziella. MiR-146b Mediates Endotoxin Tolerance in Human Phagocytes. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072152