Targeting the Mitotic Catastrophe Signaling Pathway in Cancer
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence.
Thus, failed mitotic catastrophe can promote the unrestrained growth of defective cells, thereby representing a major gateway to tumour development.
Furthermore, the activation of mitotic catastrophe offers significant therapeutic advantage which has been exploited in the action of conventional and targeted anticancer agents.
Yet, despite its importance in tumour prevention and treatment, the molecular mechanism of mitotic catastrophe is not well understood.
A better understanding of the signals that determine cell fate following failed or defective mitosis will reveal new opportunities to selectively target and enhance the programme for therapeutic benefit and reveal biomarkers to predict patient response.
This review is focused on the molecular mechanism of mitotic catastrophe induction and signalling and highlights current strategies to exploit the process in cancer therapy.
American Psychological Association (APA)
Mc Gee, Margaret M.. 2015. Targeting the Mitotic Catastrophe Signaling Pathway in Cancer. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072153
Modern Language Association (MLA)
Mc Gee, Margaret M.. Targeting the Mitotic Catastrophe Signaling Pathway in Cancer. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072153
American Medical Association (AMA)
Mc Gee, Margaret M.. Targeting the Mitotic Catastrophe Signaling Pathway in Cancer. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072153