The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients
Joint Authors
Visentainer, Jeane Eliete Laguila
Sell, Ana Maria
Sippert, Emília Ângela
Zacarias, Joana Maira Valentini
Tsuneto, Patrícia Yumeko
Silva, C.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A case-control study was conducted on patients with chronic periodontitis (CP) and healthy controls with the aim of evaluating possible association between interleukin 17A (IL17A) G197A (rs2275913) and IL17F T7488C (rs763780) polymorphisms and periodontitis.
Genotypes were determined by PCR-RFLP method.
Statistical analyses were conducted using the OpenEpi and SNPStas software to calculate Chi-square with Yates correction or Fisher’s exact tests, odds ratios (OR), and 95% confidence intervals (CIs).
SNPStas software was used to calculate Hardy-Weinberg equilibrium.
IL17A AA genotype was more frequent in patients with chronic periodontitis (CP) in the codominant and recessive models ( P = 0.09 ; OR = 2.53 and P = 0.03 ; OR = 2.46, resp.), the females with CP ( P = 0.01 , OR = 4.34), Caucasoid patients with CP ( P = 0.01 , OR = 3.45), and nonsmoking Caucasian patients with CP ( P = 0.04 , OR = 3.51).
The IL17A A allele was also more frequent in Caucasians with CP ( P = 0.04 , OR = 1.59).
IL17F T7488C polymorphism was not associated with chronic periodontitis.
In these patients from Southern Brazil, the IL17A rs2275913 polymorphisms, IL17A AA genotype, and the A allele were associated with a susceptibility to chronic periodontitis.
American Psychological Association (APA)
Zacarias, Joana Maira Valentini& Sippert, Emília Ângela& Tsuneto, Patrícia Yumeko& Visentainer, Jeane Eliete Laguila& Silva, C.& Sell, Ana Maria. 2015. The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072154
Modern Language Association (MLA)
Zacarias, Joana Maira Valentini…[et al.]. The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072154
American Medical Association (AMA)
Zacarias, Joana Maira Valentini& Sippert, Emília Ângela& Tsuneto, Patrícia Yumeko& Visentainer, Jeane Eliete Laguila& Silva, C.& Sell, Ana Maria. The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072154