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Lack of Association between Polymorphisms of the TLR4 Gene and Infection with the Hepatitis B and C Viruses
Joint Authors
Ishak, Ricardo
Santana, Bárbara B.
Feitosa, Rosimar Neris Martins
Azevedo, Vânia Nakauth
Ishak, Marluísa de O. Guimarães
Pires-Neto, Orlando de Souza
de Sá, Keyla Santos Guedes
Tatielle Monteiro Gomes, Samara
Demachki, Sâmia
da Silva Conde, Simone Regina Souza
da Silva Graça, Ednelza
Rosário Vallinoto, Antonio Carlos
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Toll-like receptor 4 (TLR4) plays a crucial role in the early recognition of pathogenic microorganisms and provides an ideal model to investigate the consequences of genetic variation and susceptibility to diseases.
The present study investigated the occurrence of the single nucleotide polymorphisms (SNPs) rs4986790 (A>G) and rs4986791 (C>T) in the TLR4 gene in chronic carriers of the hepatitis B (HBV) and C (HCV) viruses.
A total of 420 blood samples were collected (HBV, 49; HCV, 72; and controls, 299) at the liver disease outpatient clinic of Hospital da Fundação Santa Casa de Misericórdia do Pará (FSCMPA).
Genomic DNA extracted from leukocytes was subjected to real-time polymerase chain reaction (qPCR) analysis to identify the genetic profile of the participants.
No significant differences were found in the allele and genotype frequencies between the infected participants and controls.
No significant associations were found between the investigated polymorphisms and inflammatory activity, fibrosis, and the presence of cirrhosis; the same results were obtained in the haplotype analysis.
The results showed a lack of association between the rs4986790 and rs4986791 SNPs and susceptibility to infection with HBV and HCV, as well as clinical and laboratory information of the patients.
American Psychological Association (APA)
Pires-Neto, Orlando de Souza& de Sá, Keyla Santos Guedes& Santana, Bárbara B.& Tatielle Monteiro Gomes, Samara& da Silva Graça, Ednelza& da Silva Conde, Simone Regina Souza…[et al.]. 2015. Lack of Association between Polymorphisms of the TLR4 Gene and Infection with the Hepatitis B and C Viruses. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072158
Modern Language Association (MLA)
Pires-Neto, Orlando de Souza…[et al.]. Lack of Association between Polymorphisms of the TLR4 Gene and Infection with the Hepatitis B and C Viruses. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072158
American Medical Association (AMA)
Pires-Neto, Orlando de Souza& de Sá, Keyla Santos Guedes& Santana, Bárbara B.& Tatielle Monteiro Gomes, Samara& da Silva Graça, Ednelza& da Silva Conde, Simone Regina Souza…[et al.]. Lack of Association between Polymorphisms of the TLR4 Gene and Infection with the Hepatitis B and C Viruses. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072158