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Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis
Joint Authors
Wens, Inez
O Eijnde, Bert
Deckx, Nathalie
Nuyts, Amber H.
Lee, Wai-Ping
Hens, Niel
Koppen, Gudrun
Goossens, Herman
Van Damme, Pierre
Cools, Nathalie
Berneman, Zwi N.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In healthy individuals, one exercise bout induces a substantial increase in the number of circulating leukocytes, while their function is transiently suppressed.
The effect of one exercise bout in multiple sclerosis (MS) is less studied.
Since recent evidence suggests a role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of one combined endurance/resistance exercise bout on the number and function of DC in MS patients and healthy controls.
Our results show a rapid increase in the number of DC in response to physical exercise in both MS patients and controls.
Further investigation revealed that in particular DC expressing the migratory molecules CCR5 and CD62L were increased upon acute physical activity.
This may be mediated by Flt3L- and MMP-9-dependent mobilization of DC, as demonstrated by increased circulating levels of Flt3L and MMP-9 following one exercise bout.
Circulating DC display reduced TLR responsiveness after acute exercise, as evidenced by a less pronounced upregulation of activation markers, HLA-DR and CD86, on plasmacytoid DC and conventional DC, respectively.
Our results indicate mobilization of DC, which may be less prone to drive inflammatory processes, following exercise.
This may present a negative feedback mechanism for exercise-induced tissue damage and inflammation.
American Psychological Association (APA)
Deckx, Nathalie& Wens, Inez& Nuyts, Amber H.& Lee, Wai-Ping& Hens, Niel& Koppen, Gudrun…[et al.]. 2015. Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072159
Modern Language Association (MLA)
Deckx, Nathalie…[et al.]. Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072159
American Medical Association (AMA)
Deckx, Nathalie& Wens, Inez& Nuyts, Amber H.& Lee, Wai-Ping& Hens, Niel& Koppen, Gudrun…[et al.]. Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072159