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Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer
Joint Authors
Katoh, Hiroshi
Watanabe, Masahiko
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Development of solid cancer depends on escape from host immunosurveillance.
Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived suppressor cells (MDSCs).
Growing body of evidences shows that MDSCs play pivotal roles among these immunosuppressive cells in multiple steps of cancer progression.
MDSCs are immature myeloid cells that arise from myeloid progenitor cells and comprise a heterogeneous immune cell population.
MDSCs are characterized by the ability to suppress both adaptive and innate immunities mainly through direct inhibition of the cytotoxic functions of T cells and NK cells.
In clinical settings, the number of circulating MDSCs is associated with clinical stages and response to treatment in several cancers.
Moreover, MDSCs are reported to contribute to chemoresistant phenotype.
Collectively, targeting MDSCs could potentially provide a rationale for novel treatment strategies in cancer.
This review summarizes recent understandings of MDSCs in cancer and discusses promissing clinical approaches in cancer patients.
American Psychological Association (APA)
Katoh, Hiroshi& Watanabe, Masahiko. 2015. Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072160
Modern Language Association (MLA)
Katoh, Hiroshi& Watanabe, Masahiko. Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072160
American Medical Association (AMA)
Katoh, Hiroshi& Watanabe, Masahiko. Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072160