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Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
Joint Authors
Padua, Tatiana A.
Souza, Mariana C.
Henriques, Maria das Graças M. O.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Malaria is the most important parasitic disease worldwide, accounting for 1 million deaths each year.
Severe malaria is a systemic illness characterized by dysfunction of brain tissue and of one or more peripheral organs as lungs and kidney.
The most severe and most studied form of malaria is associated with cerebral complications due to capillary congestion and the adhesion of infected erythrocytes, platelets, and leukocytes to brain vasculature.
Thus, leukocyte rolling and adhesion in the brain vascular bed during severe malaria is singular and distinct from other models of inflammation.
The leukocyte/endothelium interaction and neutrophil accumulation are also observed in the lungs.
However, lung interactions differ from brain interactions, likely due to differences in the blood-brain barrier and blood-air barrier tight junction composition of the brain and lung endothelium.
Here, we review the importance of endothelial dysfunction and the mechanism of leukocyte/endothelium interaction during severe malaria.
Furthermore, we hypothesize a possible use of adjunctive therapies to antimalarial drugs that target the interaction between the leukocytes and the endothelium.
American Psychological Association (APA)
Souza, Mariana C.& Padua, Tatiana A.& Henriques, Maria das Graças M. O.. 2015. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072165
Modern Language Association (MLA)
Souza, Mariana C.…[et al.]. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072165
American Medical Association (AMA)
Souza, Mariana C.& Padua, Tatiana A.& Henriques, Maria das Graças M. O.. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072165