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Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice
Joint Authors
Rajajendram, Revathee
Tham, Chau Ling
Akhtar, Mohamad Nadeem
Israf, Daud
Sulaiman, Mohd Roslan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Asthma is associated with increased pulmonary inflammation and airway hyperresponsiveness.
The interaction between airway epithelium and inflammatory mediators plays a key role in the pathogenesis of asthma.
In vitro studies evaluated the inhibitory effects of 3-(2,5-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one (DMPF-1), a synthetic chalcone analogue, upon inflammation in the A549 lung epithelial cell line.
DMPF-1 selectively inhibited TNF-α-stimulated CC chemokine secretion (RANTES, eotaxin-1, and MCP-1) without any effect upon CXC chemokine (GRO-α and IL-8) secretion.
Western blot analysis further demonstrated that the inhibitory activity resulted from disruption of p65NF-κB nuclear translocation without any effects on the mitogen-activated protein kinase (MAPK) pathway.
Treatment of ovalbumin-sensitized and ovalbumin-challenged BALB/c mice with DMPF-1 (0.2–100 mg/kg) demonstrated significant reduction in the secretion and gene expression of CC chemokines (RANTES, eotaxin-1, and MCP-1) and Th2 cytokines (IL-4, IL-5, and IL-13).
Furthermore, DMPF-1 treatment inhibited eosinophilia, goblet cell hyperplasia, peripheral blood total IgE, and airway hyperresponsiveness in ovalbumin-sensitized and ovalbumin-challenged mice.
In conclusion, these findings demonstrate the potential of DMPF-1, a nonsteroidal compound, as an antiasthmatic agent for further pharmacological evaluation.
American Psychological Association (APA)
Rajajendram, Revathee& Tham, Chau Ling& Akhtar, Mohamad Nadeem& Sulaiman, Mohd Roslan& Israf, Daud. 2015. Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072167
Modern Language Association (MLA)
Rajajendram, Revathee…[et al.]. Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice. Mediators of Inflammation No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1072167
American Medical Association (AMA)
Rajajendram, Revathee& Tham, Chau Ling& Akhtar, Mohamad Nadeem& Sulaiman, Mohd Roslan& Israf, Daud. Inhibition of Epithelial CC-Family Chemokine Synthesis by the Synthetic Chalcone DMPF-1 via Disruption of NF-κB Nuclear Translocation and Suppression of Experimental Asthma in Mice. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072167