A Study of InflammatoryNecrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation
Joint Authors
Marino, Mariapaola
Palmieri, Giuseppe
Peruzzi, Marco
Scuderi, Flavia
Bartoccioni, Emanuela
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pertrochanteric fractures are common injuries in adults and source of morbidity and mortality among the elderly.
Different surgical techniques were recommended for their treatment but undoubtedly they add an additional inflammatory trauma along the fracture itself.
Many attempts to quantify the degree of approach-related trauma are carried out through measurements of systemic inflammatory parameters.
In this study we prospectively analyzed laboratory data of 20 patients over eighty with pertrochanteric fracture of the femur treated with proximal femoral nail antirotation (PFNA).
This is an excellent device for osteosynthesis because it can be easily and quickly inserted by a mini-incision providing stable fixation and early full mobilization.
Serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and plasma creatin kinase (CK) were evaluated 1 hour preoperatively and 24 hours postoperatively.
Our results show that PFNA did not induce significant increments in serum levels of inflammatory cytokines TNF-α and IL-6; CRP was elevated preoperatively in correlation with waiting time for surgery; CRP and CK showed a significant increment in the first postoperatory day; CK increment was correlated with surgical time length.
We conclude that, for the markers we analyzed, PFNA shows a low biomechanical-inflammatory profile that represents an advantage over other techniques.
American Psychological Association (APA)
Marino, Mariapaola& Palmieri, Giuseppe& Peruzzi, Marco& Scuderi, Flavia& Bartoccioni, Emanuela. 2015. A Study of InflammatoryNecrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072173
Modern Language Association (MLA)
Marino, Mariapaola…[et al.]. A Study of InflammatoryNecrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation. Mediators of Inflammation No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1072173
American Medical Association (AMA)
Marino, Mariapaola& Palmieri, Giuseppe& Peruzzi, Marco& Scuderi, Flavia& Bartoccioni, Emanuela. A Study of InflammatoryNecrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072173