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Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives
Joint Authors
Vitale, Antonio
Cantarini, Luca
Lopalco, Giuseppe
Lapadula, Giovanni
Anelli, Maria Grazia
Andreozzi, Laura
Galeazzi, Mauro
Rigante, Donato
Iannone, Florenzo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-16
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance, and systemic inflammation.
Due to clinical and pathophysiologic similarities giving a crucial role to the multifunctional cytokine interleukin-1, the concept of autoinflammation has been expanded to include nonhereditary collagen-like diseases, idiopathic inflammatory diseases, and metabolic diseases.
As more patients are reported to have clinical features of autoinflammation and autoimmunity, the boundary between these two pathologic ends is becoming blurred.
An overview of monogenic autoinflammatory disorders, PFAPA syndrome, rheumatoid arthritis, type 2 diabetes mellitus, uveitis, pericarditis, Behçet’s disease, gout, Sjögren’s syndrome, interstitial lung diseases, and Still’s disease is presented to highlight the fundamental points that interleukin-1 displays in the cryptic interplay between innate and adaptive immune systems.
American Psychological Association (APA)
Lopalco, Giuseppe& Cantarini, Luca& Vitale, Antonio& Iannone, Florenzo& Anelli, Maria Grazia& Andreozzi, Laura…[et al.]. 2015. Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1072176
Modern Language Association (MLA)
Lopalco, Giuseppe…[et al.]. Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives. Mediators of Inflammation No. 2015 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1072176
American Medical Association (AMA)
Lopalco, Giuseppe& Cantarini, Luca& Vitale, Antonio& Iannone, Florenzo& Anelli, Maria Grazia& Andreozzi, Laura…[et al.]. Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-21.
https://search.emarefa.net/detail/BIM-1072176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072176