Sepsis and ARDS: The Dark Side of Histones
Joint Authors
Mao, Pu
Huang, Yongbo
Li, Yimin
Xu, Zhiheng
Zhang, Jianrong
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite advances in management over the last several decades, sepsis and acute respiratory distress syndrome (ARDS) still remain major clinical challenges and the leading causes of death for patients in intensive care units (ICUs) due to insufficient understanding of the pathophysiological mechanisms of these diseases.
However, recent studies have shown that histones, also known as chromatin-basic structure proteins, could be released into the extracellular space during severe stress and physical challenges to the body (e.g., sepsis and ARDS).
Due to their cytotoxic and proinflammatory effects, extracellular histones can lead to excessive and overwhelming cell damage and death, thus contributing to the pathogenesis of both sepsis and ARDS.
In addition, antihistone-based treatments (e.g., neutralizing antibodies, activated protein C, and heparin) have shown protective effects and have significantly improved the outcomes of mice suffering from sepsis and ARDS.
Here, we review researches related to the pathological role of histone in context of sepsis and ARDS and evaluate the potential value of histones as biomarkers and therapeutic targets of these diseases.
American Psychological Association (APA)
Xu, Zhiheng& Huang, Yongbo& Mao, Pu& Zhang, Jianrong& Li, Yimin. 2015. Sepsis and ARDS: The Dark Side of Histones. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072184
Modern Language Association (MLA)
Xu, Zhiheng…[et al.]. Sepsis and ARDS: The Dark Side of Histones. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072184
American Medical Association (AMA)
Xu, Zhiheng& Huang, Yongbo& Mao, Pu& Zhang, Jianrong& Li, Yimin. Sepsis and ARDS: The Dark Side of Histones. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072184