Harnessing the Therapeutic Potential of Th17 Cells
Joint Authors
Bystrom, Jonas
Taher, Taher E.
Muhyaddin, M. Sherwan
Clanchy, Felix I.
Mangat, Pamela
Jawad, Ali S.
Williams, Richard O.
Mageed, Rizgar
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation.
The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subsequently, associated with chronic inflammation and autoimmunity.
Th17 cells have some gene profile similarity with stem cells and can remain dormant in mucosal tissues for long periods.
Indeed, recent studies suggest that functionally distinct subsets of pro- and anti-inflammatory Th17 cells can interchange phenotype and functions.
For development, Th17 cells require activation of the transcription factors STAT3 and RORγt while RUNX1, c-Maf, and Aiolos are involved in changes of phenotype/functions.
Attempts to harness Th17 cells against pathogens and cancer using vaccination strategies are being explored.
The cells gain protective abilities when induced to produce interferon γ (IFNγ).
In addition, treatment with antibodies to IL-17 is effective in treating patients with psoriasis, psoriatic arthritis, and refectory rheumatoid arthritis.
Moreover, since RORγt is a nuclear receptor, it is likely to be a potential future drug target for modulating Th17 functions.
This review explores pathways through which Th17 subsets are induced, the molecular basis of their plasticity, and potential therapeutic strategies for their modulation in diseases.
American Psychological Association (APA)
Bystrom, Jonas& Taher, Taher E.& Muhyaddin, M. Sherwan& Clanchy, Felix I.& Mangat, Pamela& Jawad, Ali S.…[et al.]. 2015. Harnessing the Therapeutic Potential of Th17 Cells. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072185
Modern Language Association (MLA)
Bystrom, Jonas…[et al.]. Harnessing the Therapeutic Potential of Th17 Cells. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072185
American Medical Association (AMA)
Bystrom, Jonas& Taher, Taher E.& Muhyaddin, M. Sherwan& Clanchy, Felix I.& Mangat, Pamela& Jawad, Ali S.…[et al.]. Harnessing the Therapeutic Potential of Th17 Cells. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072185