Dental Pulp Defence and Repair Mechanisms in Dental Caries
Joint Authors
Farges, Jean-Christophe
Alliot-Licht, Brigitte
Renard, Emmanuelle
Ducret, Maxime
Gaudin, Alexis
Smith, Anthony J.
Cooper, Paul R.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Dental caries is a chronic infectious disease resulting from the penetration of oral bacteria into the enamel and dentin.
Microorganisms subsequently trigger inflammatory responses in the dental pulp.
These events can lead to pulp healing if the infection is not too severe following the removal of diseased enamel and dentin tissues and clinical restoration of the tooth.
However, chronic inflammation often persists in the pulp despite treatment, inducing permanent loss of normal tissue and reducing innate repair capacities.
For complete tooth healing the formation of a reactionary/reparative dentin barrier to distance and protect the pulp from infectious agents and restorative materials is required.
Clinical and in vitro experimental data clearly indicate that dentin barrier formation only occurs when pulp inflammation and infection are minimised, thus enabling reestablishment of tissue homeostasis and health.
Therefore, promoting the resolution of pulp inflammation may provide a valuable therapeutic opportunity to ensure the sustainability of dental treatments.
This paper focusses on key cellular and molecular mechanisms involved in pulp responses to bacteria and in the pulpal transition between caries-induced inflammation and dentinogenic-based repair.
We report, using selected examples, different strategies potentially used by odontoblasts and specialized immune cells to combat dentin-invading bacteria in vivo.
American Psychological Association (APA)
Farges, Jean-Christophe& Alliot-Licht, Brigitte& Renard, Emmanuelle& Ducret, Maxime& Gaudin, Alexis& Smith, Anthony J.…[et al.]. 2015. Dental Pulp Defence and Repair Mechanisms in Dental Caries. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072191
Modern Language Association (MLA)
Farges, Jean-Christophe…[et al.]. Dental Pulp Defence and Repair Mechanisms in Dental Caries. Mediators of Inflammation No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1072191
American Medical Association (AMA)
Farges, Jean-Christophe& Alliot-Licht, Brigitte& Renard, Emmanuelle& Ducret, Maxime& Gaudin, Alexis& Smith, Anthony J.…[et al.]. Dental Pulp Defence and Repair Mechanisms in Dental Caries. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072191