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Neurotrauma and Inflammation: CNS and PNS Responses
Joint Authors
Martinez, Ana Maria Blanco
Mietto, Bruno Siqueira
Mostacada, Klauss
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Traumatic injury to the central nervous system (CNS) or the peripheral nervous system (PNS) triggers a cascade of events which culminate in a robust inflammatory reaction.
The role played by inflammation in the course of degeneration and regeneration is not completely elucidated.
While, in peripheral nerves, the inflammatory response is assumed to be essential for normal progression of Wallerian degeneration and regeneration, CNS trauma inflammation is often associated with poor recovery.
In this review, we discuss key mechanisms that trigger the inflammatory reaction after nervous system trauma, emphasizing how inflammations in both CNS and PNS differ from each other, in terms of magnitude, cell types involved, and effector molecules.
Knowledge of the precise mechanisms that elicit and maintain inflammation after CNS and PNS tissue trauma and their effect on axon degeneration and regeneration is crucial for the identification of possible pharmacological drugs that can positively affect the tissue regenerative capacity.
American Psychological Association (APA)
Mietto, Bruno Siqueira& Mostacada, Klauss& Martinez, Ana Maria Blanco. 2015. Neurotrauma and Inflammation: CNS and PNS Responses. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072206
Modern Language Association (MLA)
Mietto, Bruno Siqueira…[et al.]. Neurotrauma and Inflammation: CNS and PNS Responses. Mediators of Inflammation No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1072206
American Medical Association (AMA)
Mietto, Bruno Siqueira& Mostacada, Klauss& Martinez, Ana Maria Blanco. Neurotrauma and Inflammation: CNS and PNS Responses. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072206