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Cellular Response upon Stress: p57 Contribution to the Final Outcome
Joint Authors
Rossi, Marianna Nicoletta
Antonangeli, Fabrizio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Progression through the cell cycle is one of the most important decisions during the life of a cell and several kinds of stress are able to influence this choice.
p57 is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family and is a well-known regulator of the cell cycle during embryogenesis and tissue differentiation.
p57 loss has been reported in a variety of cancers and great effort has been spent during the past years studying the mechanisms of p57 regulation and the effects of p57 reexpression on tumor growth.
Recently, growing amount of evidence points out that p57 has a specific function in cell cycle regulation upon cellular stress that is only partially shared by the other CIP/KIP inhibitors p21 and p27.
Furthermore, it is nowadays emerging that p57 plays a role in the induction of apoptosis and senescence after cellular stress independently of its cell cycle related functions.
This review focuses on the contribution that p57 holds in regulating cell cycle arrest, apoptosis, and senescence after cellular stress with particular attention to the response of cancer cells.
American Psychological Association (APA)
Rossi, Marianna Nicoletta& Antonangeli, Fabrizio. 2015. Cellular Response upon Stress: p57 Contribution to the Final Outcome. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072211
Modern Language Association (MLA)
Rossi, Marianna Nicoletta& Antonangeli, Fabrizio. Cellular Response upon Stress: p57 Contribution to the Final Outcome. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072211
American Medical Association (AMA)
Rossi, Marianna Nicoletta& Antonangeli, Fabrizio. Cellular Response upon Stress: p57 Contribution to the Final Outcome. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072211