Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recent studies on innate lymphoid cells (ILCs) have expanded our knowledge about the innate arm of the immune system.
Helper-like ILCs share both the “innate” feature of conventional natural killer (cNK) cells and the “helper” feature of CD4+ T helper (Th) cells.
With this combination, helper-like ILCs are capable of initiating early immune responses similar to cNK cells, but via secretion of a set of effector cytokines similar to those produced by Th cells.
Although many studies have revealed the functional similarity between helper-like ILCs and Th cells, some aspects of ILCs including the development of this lineage remain elusive.
It is intriguing that the majority of transcription factors involved in multiple stages of T cell development, differentiation, and function also play critical roles during ILC development.
Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development.
In this review, we will summarize the expression and functions of these transcription factors shared by ILCs and Th cells.
We will also propose a complex transcriptional regulatory network for the lineage commitment of ILCs.
American Psychological Association (APA)
Zhong, Chao& Zhu, Jinfang. 2015. Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072215
Modern Language Association (MLA)
Zhong, Chao& Zhu, Jinfang. Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072215
American Medical Association (AMA)
Zhong, Chao& Zhu, Jinfang. Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072215