Microparticles That Form Immune Complexes as Modulatory Structures in Autoimmune Responses
Joint Authors
Burbano, Catalina
Rojas, Mauricio
Vásquez, Gloria
Castaño, Diana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Microparticles (MPs) are induced during apoptosis, cell activation, and even “spontaneous” release.
Initially MPs were considered to be inert cellular products with no biological function.
However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs depend upon the cellular background and the mechanism inducing them.
They possess a wide spectrum of biological effects on intercellular communication by transferring different molecules able to modulate other cells.
MPs interact with their target cells through different mechanisms: membrane fusion, macropinocytosis, and receptor-mediated endocytosis.
However, when MPs remain in the extracellular milieu, they undergo modifications such as citrullination, glycosylation, and partial proteolysis, among others, becoming a source of neoantigens.
In rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), reports indicated elevated levels of MPs with different composition, content, and effects compared with those isolated from healthy individuals.
MPs can also form immune complexes amplifying the proinflammatory response and tissue damage.
Their early detection and characterization could facilitate an appropriate diagnosis optimizing the pharmacological strategies, in different diseases including cancer, infection, and autoimmunity.
This review focuses on the current knowledge about MPs and their involvement in the immunopathogenesis of SLE and RA.
American Psychological Association (APA)
Burbano, Catalina& Rojas, Mauricio& Vásquez, Gloria& Castaño, Diana. 2015. Microparticles That Form Immune Complexes as Modulatory Structures in Autoimmune Responses. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072219
Modern Language Association (MLA)
Burbano, Catalina…[et al.]. Microparticles That Form Immune Complexes as Modulatory Structures in Autoimmune Responses. Mediators of Inflammation No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1072219
American Medical Association (AMA)
Burbano, Catalina& Rojas, Mauricio& Vásquez, Gloria& Castaño, Diana. Microparticles That Form Immune Complexes as Modulatory Structures in Autoimmune Responses. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1072219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072219