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Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
Endothelial cells form a semipermeable, regulated barrier that limits the passage of fluid, small molecules, and leukocytes between the bloodstream and the surrounding tissues.
The adherens junction, a major mechanism of intercellular adhesion, is comprised of transmembrane cadherins forming homotypic interactions between adjacent cells and associated cytoplasmic catenins linking the cadherins to the cytoskeleton.
Inflammatory conditions promote the disassembly of the adherens junction and a loss of intercellular adhesion, creating openings or gaps in the endothelium through which small molecules diffuse and leukocytes transmigrate.
Tyrosine kinase signaling has emerged as a central regulator of the inflammatory response, partly through direct phosphorylation and dephosphorylation of the adherens junction components.
This review discusses the findings that support and those that argue against a direct effect of cadherin and catenin phosphorylation in the disassembly of the adherens junction.
Recent findings indicate a complex interaction between kinases, phosphatases, and the adherens junction components that allow a fine regulation of the endothelial permeability to small molecules, leukocyte migration, and barrier resealing.
American Psychological Association (APA)
Adam, Alejandro Pablo. 2015. Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1072221
Modern Language Association (MLA)
Adam, Alejandro Pablo. Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation. Mediators of Inflammation No. 2015 (2015), pp.1-24.
https://search.emarefa.net/detail/BIM-1072221
American Medical Association (AMA)
Adam, Alejandro Pablo. Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-24.
https://search.emarefa.net/detail/BIM-1072221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072221