Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases
Joint Authors
Yang, Heping
Liu, Ting
Zhou, Yu
Ko, Kwang Suk
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro- and anti-inflammatory mediators in the liver.
These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumorigenesis.
c-Myc is involved in many cellular events such as cell growth, proliferation, and differentiation.
c-Myc upregulates IL-8, IL-10, TNF-α, and TGF-β, while IL-1, IL-2, IL-4, TNF-α, and TGF-β promote c-Myc expression.
Their interactions play a central role in fibrosis, cirrhosis, and liver cancer.
Molecular interference of their interactions offers possible therapeutic potential for CLDs.
In this review, current knowledge of the molecular interactions between c-Myc and various well known inflammatory mediators is discussed.
American Psychological Association (APA)
Liu, Ting& Zhou, Yu& Ko, Kwang Suk& Yang, Heping. 2015. Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072226
Modern Language Association (MLA)
Liu, Ting…[et al.]. Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072226
American Medical Association (AMA)
Liu, Ting& Zhou, Yu& Ko, Kwang Suk& Yang, Heping. Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072226