N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALBC Mice
Joint Authors
Lan, Hui Y.
Chan, Gary C. W.
Yiu, Wai Han
Wu, Hao Jia
Wong, Dickson W. L.
Lin, Miao
Huang, Xiao Ru
Tang, Sydney C. W.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To expand the armamentarium of treatment for chronic kidney disease (CKD), we explored the utility of boosting endogenously synthesized N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), which is augmented by inhibition of the angiotensin converting enzyme.
Male BALB/c mice underwent unilateral ureteral ligation (UUO) or sham operation and received exogenously administered Ac-SDKP delivered via a subcutaneous osmotic minipump or Captopril treatment by oral gavage.
Seven days after UUO, there were significant reductions in the expression of both collagen 1 and collagen 3 in kidneys treated with Ac-SDKP or Captopril, and there was a trend towards reductions in collagen IV, α-SMA, and MCP-1 versus control.
However, no significant attenuation of interstitial injury or macrophage infiltration was observed.
These findings are in contrary to observations in other models and underscore the fact that a longer treatment time frame may be required to yield anti-inflammatory effects in BALB/c mice treated with Ac-SDKP compared to untreated mice.
Finding an effective treatment regimen for CKD requires fine-tuning of pharmacologic protocols.
American Psychological Association (APA)
Chan, Gary C. W.& Yiu, Wai Han& Wu, Hao Jia& Wong, Dickson W. L.& Lin, Miao& Huang, Xiao Ru…[et al.]. 2015. N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALBC Mice. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072231
Modern Language Association (MLA)
Chan, Gary C. W.…[et al.]. N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALBC Mice. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072231
American Medical Association (AMA)
Chan, Gary C. W.& Yiu, Wai Han& Wu, Hao Jia& Wong, Dickson W. L.& Lin, Miao& Huang, Xiao Ru…[et al.]. N-Acetyl-seryl-aspartyl-lysyl-proline Alleviates Renal Fibrosis Induced by Unilateral Ureteric Obstruction in BALBC Mice. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072231