RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress

Joint Authors

Hsieh, Rong-Hong
Cho, Er-Chieh
Kuo, Mei-Ling
Cheng, Jia-hui
Cheng, Yu-Chi
Hsieh, Yi-Chen
Liu, Yun-Ru
Yen, Yun

Source

Mediators of Inflammation

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-05-18

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule.

The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B.

However, the p53-independent regulation of RRM2B, particularly under oxidative stress, remains largely unknown.

In this study, we investigated the role of RRM2B underoxidative stress-induced DNA damage and further examined the regulation of mitochondrial and inflammatory genes by RRM2B.

Our study is the first to report the critical role of RRM2B in mitochondrial homeostasis and the inflammation signaling pathway in a p53-independent manner.

Furthermore, our study provides novel insights into the role of the RR in inflammatory diseases.

American Psychological Association (APA)

Cho, Er-Chieh& Kuo, Mei-Ling& Cheng, Jia-hui& Cheng, Yu-Chi& Hsieh, Yi-Chen& Liu, Yun-Ru…[et al.]. 2015. RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072233

Modern Language Association (MLA)

Cho, Er-Chieh…[et al.]. RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072233

American Medical Association (AMA)

Cho, Er-Chieh& Kuo, Mei-Ling& Cheng, Jia-hui& Cheng, Yu-Chi& Hsieh, Yi-Chen& Liu, Yun-Ru…[et al.]. RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072233

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1072233