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The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung
Joint Authors
Weldon, Sinéad
Taggart, Clifford C.
Twigg, Matthew S.
Brockbank, Simon
Lowry, Philip
FitzGerald, S. Peter
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cystic fibrosis (CF) lung disease is an inherited condition with an incidence rate of approximately 1 in 2500 new born babies.
CF is characterized as chronic infection of the lung which leads to inflammation of the airway.
Sputum from CF patients contains elevated levels of neutrophils and subsequently elevated levels of neutrophil serine proteases.
In a healthy individual these proteases aid in the phagocytic process by degrading microbial peptides and are kept in homeostatic balance by cognate antiproteases.
Due to the heavy neutrophil burden associated with CF the high concentration of neutrophil derived proteases overwhelms cognate antiproteases.
The general effects of this protease/antiprotease imbalance are impaired mucus clearance, increased and self-perpetuating inflammation, and impaired immune responses and tissue.
To restore this balance antiproteases have been suggested as potential therapeutics or therapeutic targets.
As such a number of both endogenous and synthetic antiproteases have been trialed with mixed success as therapeutics for CF lung disease.
American Psychological Association (APA)
Twigg, Matthew S.& Brockbank, Simon& Lowry, Philip& FitzGerald, S. Peter& Taggart, Clifford C.& Weldon, Sinéad. 2015. The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072237
Modern Language Association (MLA)
Twigg, Matthew S.…[et al.]. The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072237
American Medical Association (AMA)
Twigg, Matthew S.& Brockbank, Simon& Lowry, Philip& FitzGerald, S. Peter& Taggart, Clifford C.& Weldon, Sinéad. The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072237