Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2mPGES-1PGE2 Cascade
Joint Authors
Yang, Tianxin
Wang, Haiping
Sun, Jing
Xu, Liang
Zhao, Bing
Yu, Kezhou
Yang, Meng
Wang, Rong
Jia, Zhanjun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nitrooleic acid (OA-NO2) is an endogenous lipid product which has novel signaling properties, particularly the activation of peroxisome proliferator-activated receptors.
The current study aimed to evaluate the protective effects of OA-NO2 against cisplatin-induced kidney injury in mice.
Mice were pretreated with OA-NO2 for 48 h before cisplatin administration, and the cisplatin-caused nephrotoxicity was evaluated.
After the cisplatin treatment (72 h), the vehicle-treated mice displayed renal dysfunction, as evidenced by the elevated plasma urea and creatinine, which was consistent with the histological damage, such as tubular necrosis, dilation, protein cast, and desquamation of epithelial cells.
In contrast, the severity of the renal dysfunction and histological change were reduced in the OA-NO2 pretreated mice.
The renal COX-2 and mPGES-1 mRNAs and their respective proteins expression, together with the renal PGE2 amounts, were induced by the cisplatin treatment, but their initiation was reduced by OA-NO2.
Moreover, the circulating TNF-α, renal TNF-α, IL-1β, MCP-1, ICAM-1, and VACAM-1 mRNA levels were higher in the cisplatin-treated mice, compared with the controls, but they were attenuated in the OA-NO2 pretreatment group.
In summary, the pretreatment with OA-NO2 remarkably ameliorated the cisplatin-induced kidney injury in mice, possibly via the inhibition of the inflammatory response, associated with the COX-2/mPGES-1/PGE2 cascade.
American Psychological Association (APA)
Wang, Haiping& Jia, Zhanjun& Sun, Jing& Xu, Liang& Zhao, Bing& Yu, Kezhou…[et al.]. 2015. Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2mPGES-1PGE2 Cascade. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072239
Modern Language Association (MLA)
Wang, Haiping…[et al.]. Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2mPGES-1PGE2 Cascade. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072239
American Medical Association (AMA)
Wang, Haiping& Jia, Zhanjun& Sun, Jing& Xu, Liang& Zhao, Bing& Yu, Kezhou…[et al.]. Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2mPGES-1PGE2 Cascade. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072239