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Cardiac Migration of Endogenous Mesenchymal Stromal Cells in Patients with Inflammatory Cardiomyopathy
Joint Authors
Kühl, Uwe
Schultheiss, Heinz-Peter
Schmidt-Lucke, Caroline
Van Linthout, Sophie
Miteva, Kapka
Ringe, Jochen
Zobel, Thomas
Tschöpe, Carsten
Escher, Felicitas
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Mesenchymal stromal cells (MSC) have immunomodulatory features.
The aim of this study was to investigate the migration and homing potential of endogenous circulating MSC in virus negative inflammatory cardiomyopathy (CMi).
Methods.
In 29 patients with n=23 or without n=6 CMi undergoing endomyocardial biopsies (EMB), transcardiac gradients (TCGs) of circulating MSC were measured by flow cytometry from blood simultaneously sampled from aorta and coronary sinus.
The presence of MSC in EMB, cardiac inflammation, and SDF-1α mRNA expression were detected via immunohistochemistry and real-time PCR.
Results.
MSC defined as CD45−CD34−CD11b−CD73+CD90+ cells accounted for 0.010 [0.0025–0.048]%/peripheral mononuclear cell (PMNC) and as CD45−CD34−CD11b−CD73+CD105+ cells for 0.019 [0.0026–0.067]%/PMNC, both with similar counts in patients with or without cardiac inflammation.
There was a 29.9% P<0.01 transcardiac reduction of circulating MSC in patients with CMi, correlating with the extent of cardiac inflammation (P<0.05, multivariate analysis).
A strong correlation was found between the TCG of circulating MSC and numbers of MSC (CD45−CD34−CD90+CD105+) in EMB (r=-0.73, P<0.005).
SDF-1α was the strongest predictor for increased MSC in EMB (P<0.005, multivariate analysis).
Conclusions.
Endogenous MSC continuously migrate to the heart in patients with CMi triggered by cardiac inflammation.
American Psychological Association (APA)
Schmidt-Lucke, Caroline& Escher, Felicitas& Van Linthout, Sophie& Kühl, Uwe& Miteva, Kapka& Ringe, Jochen…[et al.]. 2015. Cardiac Migration of Endogenous Mesenchymal Stromal Cells in Patients with Inflammatory Cardiomyopathy. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072242
Modern Language Association (MLA)
Schmidt-Lucke, Caroline…[et al.]. Cardiac Migration of Endogenous Mesenchymal Stromal Cells in Patients with Inflammatory Cardiomyopathy. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072242
American Medical Association (AMA)
Schmidt-Lucke, Caroline& Escher, Felicitas& Van Linthout, Sophie& Kühl, Uwe& Miteva, Kapka& Ringe, Jochen…[et al.]. Cardiac Migration of Endogenous Mesenchymal Stromal Cells in Patients with Inflammatory Cardiomyopathy. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072242