Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial
Joint Authors
Di Renzo, Laura
Gratteri, Santo
Carraro, Alberto
Valente, Roberto
Gualtieri, Paola
Tomasi, Diego
Gaiotti, Federica
De Lorenzo, Antonino
Marsella, Luigi Tonino
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Postprandial oxidative stress is characterized by an increased susceptibility of the organism towards oxidative damage after consumption of a meal rich in lipids and/or carbohydrates.
Micronutrients modulate immune system and exert a protective action by reducing low density lipoproteins (LDL) oxidation via induction of antioxidant enzymes.
We evaluated the gene expression of oxidative stress (HOSp), inflammasome (HIp), and human drug metabolism pathways (HDM) and ox-LDL level at baseline and after the intake of red wine naturally enriched with resveratrol (NPVRW), in association with or without a McDonald’s meal (McDM).
The ox-LDL levels significantly increase comparing baseline (B) versus McDM and decreased comparing McDM versus McDM + NPVRW (P≤0.05).
Percentages of significant genes expressed after each nutritional intervention were the following: (1) B versus McDM, 2.88% HOSp, 2.40% of HIp, and 3.37% of HDMp; (2) B versus McDM + NPVRW, 1.44% of HOSp, 4.81% of HIp, and 0.96% of HDMp; (3) McDM versus McDM + NPVRW, 2.40% of HOSp, 2.40% of HIp, and 5.77% of HDMp; (4) B versus NPVRW, 4.80% HOSp, 3.85% HIp, and 3.85% HDMp.
NPVRW intake reduced postprandial ox-LDL and the expression of inflammation and oxidative stress related genes.
Chronic studies on larger population are necessary before definitive conclusions.
American Psychological Association (APA)
Di Renzo, Laura& Marsella, Luigi Tonino& Carraro, Alberto& Valente, Roberto& Gualtieri, Paola& Gratteri, Santo…[et al.]. 2015. Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072245
Modern Language Association (MLA)
Di Renzo, Laura…[et al.]. Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072245
American Medical Association (AMA)
Di Renzo, Laura& Marsella, Luigi Tonino& Carraro, Alberto& Valente, Roberto& Gualtieri, Paola& Gratteri, Santo…[et al.]. Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072245