Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial

Joint Authors

Di Renzo, Laura
Gratteri, Santo
Carraro, Alberto
Valente, Roberto
Gualtieri, Paola
Tomasi, Diego
Gaiotti, Federica
De Lorenzo, Antonino
Marsella, Luigi Tonino

Source

Mediators of Inflammation

Issue

Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-05-25

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases

Abstract EN

Postprandial oxidative stress is characterized by an increased susceptibility of the organism towards oxidative damage after consumption of a meal rich in lipids and/or carbohydrates.

Micronutrients modulate immune system and exert a protective action by reducing low density lipoproteins (LDL) oxidation via induction of antioxidant enzymes.

We evaluated the gene expression of oxidative stress (HOSp), inflammasome (HIp), and human drug metabolism pathways (HDM) and ox-LDL level at baseline and after the intake of red wine naturally enriched with resveratrol (NPVRW), in association with or without a McDonald’s meal (McDM).

The ox-LDL levels significantly increase comparing baseline (B) versus McDM and decreased comparing McDM versus McDM + NPVRW (P≤0.05).

Percentages of significant genes expressed after each nutritional intervention were the following: (1) B versus McDM, 2.88% HOSp, 2.40% of HIp, and 3.37% of HDMp; (2) B versus McDM + NPVRW, 1.44% of HOSp, 4.81% of HIp, and 0.96% of HDMp; (3) McDM versus McDM + NPVRW, 2.40% of HOSp, 2.40% of HIp, and 5.77% of HDMp; (4) B versus NPVRW, 4.80% HOSp, 3.85% HIp, and 3.85% HDMp.

NPVRW intake reduced postprandial ox-LDL and the expression of inflammation and oxidative stress related genes.

Chronic studies on larger population are necessary before definitive conclusions.

American Psychological Association (APA)

Di Renzo, Laura& Marsella, Luigi Tonino& Carraro, Alberto& Valente, Roberto& Gualtieri, Paola& Gratteri, Santo…[et al.]. 2015. Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072245

Modern Language Association (MLA)

Di Renzo, Laura…[et al.]. Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072245

American Medical Association (AMA)

Di Renzo, Laura& Marsella, Luigi Tonino& Carraro, Alberto& Valente, Roberto& Gualtieri, Paola& Gratteri, Santo…[et al.]. Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072245

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1072245