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Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia
Joint Authors
Naruse, Katsuhiko
Kobayashi, Hiroshi
Tsunemi, Taihei
Akasaka, Juria
Shigemitsu, Aiko
Koike, Natsuki
Yoshimoto, Chiharu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
The pathophysiology of preeclampsia is characterized by abnormal placentation, an exaggerated inflammatory response, and generalized dysfunction of the maternal endothelium.
We investigated the effects of preeclampsia serum on the expression of inflammation-related genes by adipose tissue.
Materials and Methods.
Visceral adipose tissue was obtained from the omentum of patients with early ovarian cancer without metastasis.
Adipose tissue was incubated with sera obtained from either five women affected with severe preeclampsia or five women from control pregnant women at 37°C in a humidified incubator at 5% CO2 for 24 hours.
370 genes in total mRNA were analyzed with quantitative RT-PCR (Inflammatory Response & Autoimmunity gene set).
Results.
Gene expression analysis revealed changes in the expression levels of 30 genes in adipose tissue treated with preeclampsia sera.
Some genes are related to immune response, oxidative stress, insulin resistance, and adipogenesis, which plays a central role in excessive systemic inflammatory response of preeclampsia.
In contrast, other genes have shown beneficial effects in the regulation of Th2 predominance, antioxidative stress, and insulin sensitivity.
Conclusion.
In conclusion, visceral adipose tissue offers protection against inflammation, oxidative insults, and other forms of cellular stress that are central to the pathogenesis of preeclampsia.
American Psychological Association (APA)
Naruse, Katsuhiko& Akasaka, Juria& Shigemitsu, Aiko& Tsunemi, Taihei& Koike, Natsuki& Yoshimoto, Chiharu…[et al.]. 2015. Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072248
Modern Language Association (MLA)
Naruse, Katsuhiko…[et al.]. Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072248
American Medical Association (AMA)
Naruse, Katsuhiko& Akasaka, Juria& Shigemitsu, Aiko& Tsunemi, Taihei& Koike, Natsuki& Yoshimoto, Chiharu…[et al.]. Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072248