Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery
Joint Authors
Lin, Feng-Yen
Li, Chi-Yuan
Lin, Yi-Wen
Tsai, Chien-Sung
Lin, Tso-Chou
Hsu, Che-Hao
Huang, Go-Shine
Wu, Zhi-Fu
Tsai, Yi-Ting
Lin, Chih-Yuan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction.
The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB.
Methods.
Thirty patients undergoing elective cardiac surgery were included.
Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA.
The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded.
Results.
The plasma MMP-9 concentrations significantly elevated at 2–6 h after beginning CPB (P<0.001) and returned to the preanesthesia level at 24 h (P=0.23), with predominant neutrophil counts after surgery (P<0.001).
The plasma MMP-9 levels at 4 and 6 h were not correlated with prolonged CPB time and displayed no association with postoperative PaO2/FiO2, regardless of reduced ratio from preoperative 342.9±81.2 to postoperative 207.3±121.3 mmHg (P<0.001).
Conclusion.
Elective cardiac surgery with CPB induced short-term elevation of plasma MMP-9 concentrations within 24 hours, however, without significant correlation with CPB time and postoperative pulmonary dysfunction, despite predominantly increased neutrophils and reduced oxygenation.
American Psychological Association (APA)
Lin, Tso-Chou& Lin, Feng-Yen& Lin, Yi-Wen& Hsu, Che-Hao& Huang, Go-Shine& Wu, Zhi-Fu…[et al.]. 2015. Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072254
Modern Language Association (MLA)
Lin, Tso-Chou…[et al.]. Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery. Mediators of Inflammation No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1072254
American Medical Association (AMA)
Lin, Tso-Chou& Lin, Feng-Yen& Lin, Yi-Wen& Hsu, Che-Hao& Huang, Go-Shine& Wu, Zhi-Fu…[et al.]. Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1072254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072254