Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes
Joint Authors
Fraga-Silva, Thais F. C.
Mimura, Luiza A. N.
Marchetti, Camila M.
Venturini, James
Golim, Marjorie Assis
Locachevic, Gisele A.
Arruda, Maria S. P.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dermatophytes are fungi responsible for causing superficial infections.
In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent.
In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experimental infection by Trichophyton mentagrophytes as well as alterations in the mononuclear phagocytes.
Our results showed two distinct profiles of fungal outcome and immune response.
Short term HH induced a discrete impaired proinflammatory response by peritoneal adherent cells (PAC) and a delayed fungal clearance.
Moreover, long term HH mice showed low and persistent fungal load and a marked reduction in the production of TNF-α by PAC.
Furthermore, while the inoculation of TM in non-HH mice triggered high influx of Gr1+ monocytes into the peripheral blood, long term HH mice showed low percentage of these cells.
Thus, our results demonstrate that the time of exposure of HH interferes with the TM infection outcome as well as the immunobiology of mononuclear phagocytes, including fresh monocyte recruitment from bone marrow and PAC activity.
American Psychological Association (APA)
Fraga-Silva, Thais F. C.& Marchetti, Camila M.& Mimura, Luiza A. N.& Locachevic, Gisele A.& Golim, Marjorie Assis& Venturini, James…[et al.]. 2015. Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072255
Modern Language Association (MLA)
Fraga-Silva, Thais F. C.…[et al.]. Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072255
American Medical Association (AMA)
Fraga-Silva, Thais F. C.& Marchetti, Camila M.& Mimura, Luiza A. N.& Locachevic, Gisele A.& Golim, Marjorie Assis& Venturini, James…[et al.]. Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072255