Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension
Joint Authors
Hashizume, Makoto
Kotani, Kohei
Kawabe, Joji
Morikawa, Hiroyasu
Akahoshi, Tomohiko
Shiomi, Susumu
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The functions of genes involved in idiopathic portal hypertension (IPH) remain unidentified.
The present study was undertaken to identify the functions of genes expressed in bloodsamples from patients with IPH through comprehensive analysis of gene expression usingDNA microarrays.
The data were compared with data from healthy individuals to explore thefunctions of genes showing increased or decreased expression in patients with IPH.
In clusteranalysis, no dominant probe group was shown to differ between patients with IPH and healthycontrols.
In functional annotation analysis using the Database for Annotation Visualizationand Integrated Discovery tool, clusters showing dysfunction in patients with IPH involvedgene terms related to the immune system.
Analysis using network-based pathways revealeddecreased expression of adenosine deaminase, ectonucleoside triphosphatediphosphohydrolase 4, ATP-binding cassette, subfamily C, member 1, transforming growthfactor-β, and prostaglandin E receptor 2; increased expression of cytochrome P450, family 4,subfamily F, polypeptide 3, and glutathione peroxidase 3; and abnormalities in the immunesystem, nucleic acid metabolism, arachidonic acid/leukotriene pathways, and biologicalprocesses.
These results suggested that IPH involved compromised function ofimmunocompetent cells and that such dysfunction may be associated with abnormalities innucleic acid metabolism and arachidonic acid/leukotriene-related synthesis/metabolism.
American Psychological Association (APA)
Kotani, Kohei& Kawabe, Joji& Morikawa, Hiroyasu& Akahoshi, Tomohiko& Hashizume, Makoto& Shiomi, Susumu. 2015. Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072261
Modern Language Association (MLA)
Kotani, Kohei…[et al.]. Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072261
American Medical Association (AMA)
Kotani, Kohei& Kawabe, Joji& Morikawa, Hiroyasu& Akahoshi, Tomohiko& Hashizume, Makoto& Shiomi, Susumu. Comprehensive Screening of Gene Function and Networks by DNA Microarray Analysis in Japanese Patients with Idiopathic Portal Hypertension. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072261