Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage
Joint Authors
Xu, Hong-Xi
Zhang, Dan-Dan
Zhang, Hong
Wu, Rong
Xu, Jin-wen
Murad, Ferid
Bian, Ka
Lao, Yuanzhi
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Garcinia Linn.
plants having rich natural xanthones and benzophenones with anti-inflammatory activity attracted a great deal of attention to discover and develop them as potential drug candidates.
Through screening targeting nitric oxide accumulation in stimulated macrophage, we found that 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (TIE) had potential anti-inflammatory effect.
To understand how TIE elicits its anti-inflammatory activity, we uncovered that it significantly inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS/IFNγ-stimulated RAW264.7 cells.
In further study, we showed that TIE reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), two key molecules responsible for the production of NO and PGE2 during inflammation progress.
Additionally, TIE also suppressed the expression of inflammatory cytokines IL-6, IL-12, and TNF-α.
TIE-led suppression in iNOS, COX-2, and cytokines production were probably the consequence of TIE’s capability to block ERK and p38MAPK signaling pathway.
Moreover, TIE blocked activation of nuclear factor-kappa B (NF-κB) as well as NF-κB regulation of miR155 expression.
Our study suggests that TIE may represent as a potential therapeutic agent for the treatment of inflammatory diseases.
American Psychological Association (APA)
Zhang, Dan-Dan& Zhang, Hong& Lao, Yuanzhi& Wu, Rong& Xu, Jin-wen& Murad, Ferid…[et al.]. 2015. Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072262
Modern Language Association (MLA)
Zhang, Dan-Dan…[et al.]. Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072262
American Medical Association (AMA)
Zhang, Dan-Dan& Zhang, Hong& Lao, Yuanzhi& Wu, Rong& Xu, Jin-wen& Murad, Ferid…[et al.]. Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072262