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Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants
Joint Authors
Brown, C.
Bakillah, Ahmed
Ayoub, Isabelle
John, Devon
Hussain, M. Mahmood
Norin, Allen J.
Tedla, F. M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Functional abnormalities of high-density lipoprotein (HDL) could contribute to cardiovascular disease in chronic kidney disease patients.
We measured a validated marker of HDL dysfunction, nitrated apolipoprotein A-I, in kidney transplant recipients to test the hypothesis that a functioning kidney transplant reduces serum nitrated apoA-I concentrations.
Methods.
Concentrations of nitrated apoA-I and apoB were measured using indirect sandwich ELISA assays on sera collected from each transplant subject before transplantation and at 1, 3, and 12 months after transplantation.
Patients were excluded if they have history of diabetes, treatment with lipid-lowering medications or HIV protease inhibitors, prednisone dose > 15 mg/day, nephrotic range proteinuria, serum creatinine > 1.5 mg/dL, or active inflammatory disease.
Sera from 18 transplanted patients were analyzed.
Four subjects were excluded due to insufficient data.
Twelve and eight patients had creatinine < 1.5 mg/dL at 3 and 12 months after transplantation, respectively.
Results.
Nitrated apoA-I was significantly reduced at 12 months after transplantation (p=0.039).
The decrease in apoA-I nitration was associated with significant reduction in myeloperoxidase (MPO) activity (p=0.047).
In contrast to apoA-I, nitrated apoB was not affected after kidney transplantation.
Conclusions.
Patients with well-functioning grafts had significant reduction in nitrated apoA-I 12 months after kidney transplantation.
Further studies are needed in a large cohort to determine if nitrated apoA-I can be used as a valuable marker for cardiovascular risk stratification in chronic kidney disease.
American Psychological Association (APA)
Bakillah, Ahmed& Tedla, F. M.& Ayoub, Isabelle& John, Devon& Norin, Allen J.& Hussain, M. Mahmood…[et al.]. 2015. Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072265
Modern Language Association (MLA)
Bakillah, Ahmed…[et al.]. Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072265
American Medical Association (AMA)
Bakillah, Ahmed& Tedla, F. M.& Ayoub, Isabelle& John, Devon& Norin, Allen J.& Hussain, M. Mahmood…[et al.]. Plasma Nitration of High-Density and Low-Density Lipoproteins in Chronic Kidney Disease Patients Receiving Kidney Transplants. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072265