Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes
Joint Authors
Peter, Karlheinz
Thiele, J. R.
Zeller, J.
Bannasch, H.
Eisenhardt, S. U.
Stark, Gerd Bjoern
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
C-reactive protein (CRP) is a pentraxin that has long been employed as a marker of inflammation in clinical practice.
Recent findings brought up the idea of CRP to be not only a systemic marker but also a mediator of inflammation.
New studies focused on structural changes of the plasma protein, revealing the existence of two distinct protein conformations associated with opposed inflammatory properties.
Native, pentameric CRP (pCRP) is considered to be the circulating precursor form of monomeric CRP (mCRP) that has been identified to be strongly proinflammatory.
Recently, a dissociation mechanism of pCRP has been identified on activated platelets and activated/apoptotic cells associated with the amplification of the proinflammatory potential.
Correspondingly, CRP deposits found in inflamed tissues have been identified to exhibit the monomeric conformation by using conformation-specific antibodies.
Here we review the current literature on the causal role of the dissociation mechanism of pCRP and the genesis of mCRP for the amplification of the proinflammatory potential in inflammatory reactions such as atherosclerosis and ischemia/reperfusion injury.
The chance to prevent the formation of proinflammatory mediators in ubiquitous inflammatory cascades has pushed therapeutic strategies by targeting pCRP dissociation in inflammation.
In this respect, the development of clinically applicable derivatives of the palindromic compound 1,6-bis(phosphocholine)-hexane (1,6-bis PC) should be a major focus of future CRP research.
American Psychological Association (APA)
Thiele, J. R.& Zeller, J.& Bannasch, H.& Stark, Gerd Bjoern& Peter, Karlheinz& Eisenhardt, S. U.. 2015. Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072286
Modern Language Association (MLA)
Thiele, J. R.…[et al.]. Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072286
American Medical Association (AMA)
Thiele, J. R.& Zeller, J.& Bannasch, H.& Stark, Gerd Bjoern& Peter, Karlheinz& Eisenhardt, S. U.. Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072286