![](/images/graphics-bg.png)
Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome
Joint Authors
Arnesen, Harald
Seljeflot, Ingebjørg
Laake, Kristian
Fagerland, Morten Wang
Njerve, Ida Unhammer
Solheim, Svein
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Fractalkine is a chemokine associated with atherosclerosis.
Increased serum levels have been reported in unstable coronary artery disease (CAD) and to predict mortality in heart failure.
Mediterranean-like diet and omega-3 fatty acids (n3-PUFA) have documented cardioprotective and anti-inflammatory effects.
We have investigated the effect of Mediterranean-like dietary counseling and n-3 PUFA on serum fractalkine in an elderly population and its ability to predict cardiovascular disease (CVD).
Materials and Methods.
563 men (age 64–75 yrs) at high risk of CAD were randomized into a 2 × 2 factorial designed trial for 3-year dietary counseling and/or n-3 PUFA supplementation (2.4 g/d).
Circulating levels of fractalkine were measured at baseline and at end of study.
Clinical events were recorded after 3 years.
Results.
Fractalkine levels were significantly reduced in all groups from baseline to 3 years ( P < 0.001 , all), but without between-group differences in changes.
Fractalkine levels at baseline were not predictive for CVD events ( n = 68 ) or total mortality.
Lower fractalkine levels were observed in smokers ( P = 0.019 ).
Conclusions.
Reduced levels of fractalkine from baseline to 3 years were observed, however, without any influence of Mediterranean-like diet or n-3 PUFA supplementation.
Fractalkine levels at baseline were not predictive for later CVD events.
American Psychological Association (APA)
Laake, Kristian& Seljeflot, Ingebjørg& Fagerland, Morten Wang& Njerve, Ida Unhammer& Arnesen, Harald& Solheim, Svein. 2015. Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072290
Modern Language Association (MLA)
Laake, Kristian…[et al.]. Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072290
American Medical Association (AMA)
Laake, Kristian& Seljeflot, Ingebjørg& Fagerland, Morten Wang& Njerve, Ida Unhammer& Arnesen, Harald& Solheim, Svein. Effects on Serum Fractalkine by Diet and Omega-3 Fatty Acid Intervention: Relation to Clinical Outcome. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072290