A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients
Joint Authors
Wu, Mei-Shin
Chen, Hsiang-Yin
Khaleel, Anas
Wong, Henry Sung-Ching
Hsu, Yu-Wen
Chou, Yii-Her
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause.
Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria.
Therefore, TRPV5 was suggested to be involved in calcium homeostasis.
However, whether genetic polymorphisms of TRPV5 are associated with kidney stone multiplicity or recurrence is unclear.
In this study, 365 Taiwanese kidney-stone patients were recruited.
Both biochemical data and DNA samples were collected.
Genotyping was performed by a TaqMan allelic discrimination assay.
We found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype (p=0.0271).
In summary, despite the complexity of nephrolithiasis and the potential association of numerous calcium homeostatic absorption/reabsorption factors, TRPV5 plays an important role in the pathogenesis of calcium nephrolithiasis.
American Psychological Association (APA)
Khaleel, Anas& Wu, Mei-Shin& Wong, Henry Sung-Ching& Hsu, Yu-Wen& Chou, Yii-Her& Chen, Hsiang-Yin. 2015. A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072292
Modern Language Association (MLA)
Khaleel, Anas…[et al.]. A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072292
American Medical Association (AMA)
Khaleel, Anas& Wu, Mei-Shin& Wong, Henry Sung-Ching& Hsu, Yu-Wen& Chou, Yii-Her& Chen, Hsiang-Yin. A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072292