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Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis
Joint Authors
Sessa, Rosa
Di Pietro, Marisa
Farcomeni, Alessio
Filardo, Simone
Schiavoni, Giovanna
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Several studies have attempted to relate the C.
pneumoniae-mediated inflammatory state with atherosclerotic cardiovascular diseases, providing inconsistent results.
Therefore, we performed a meta-analysis to clarify whether C.
pneumoniae may contribute to the pathogenesis of atherosclerosis by enhancing inflammation.
12 case-control, 6 cross-sectional, and 7 prospective studies with a total of 10,176 patients have been included in this meta-analysis.
Odds Ratio (OR) with a 95% confidence interval was used to assess the seroprevalence of C.
pneumoniae and differences between levels of inflammatory markers were assessed by standard mean differences.
Publication bias was performed to ensure the statistical power.
hsCRP, fibrinogen, interleukin- (IL-) 6, TNF-α, and IFN-γ showed a significant increase in patients with atherosclerosis compared to healthy controls ( P < 0.05 ), along with a higher seroprevalence of C.
pneumoniae (OR of 3.11, 95% CI: 2.88–3.36, P < 0.001 ).
More interestingly, hsCRP, IL-6, and fibrinogen levels were significantly higher in C.
pneumoniae IgA seropositive compared to seronegative atherosclerotic patients ( P < 0.0001 ).
In conclusion, the present meta-analysis suggests that C.
pneumoniae infection may contribute to atherosclerotic cardiovascular diseases by enhancing the inflammatory state, and, in particular, seropositivity to C.
pneumoniae IgA, together with hsCRP, fibrinogen, and IL-6, may be predictive of atherosclerotic cardiovascular risk.
American Psychological Association (APA)
Filardo, Simone& Di Pietro, Marisa& Farcomeni, Alessio& Schiavoni, Giovanna& Sessa, Rosa. 2015. Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072293
Modern Language Association (MLA)
Filardo, Simone…[et al.]. Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072293
American Medical Association (AMA)
Filardo, Simone& Di Pietro, Marisa& Farcomeni, Alessio& Schiavoni, Giovanna& Sessa, Rosa. Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072293