Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients
Joint Authors
D'Ettorre, Gabriella
Antonelli, Guido
Andreotti, Mauro
Selvaggi, Carla
Giustini, Noemi
Serafino, Sara
Schietroma, Ivan
Scagnolari, Carolina
Vullo, Vincenzo
Ceccarelli, Giancarlo
Nunnari, Giuseppe
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The complex relationship between both the Th1/Th17 and Tc1/Tc17 axis and innate defences in the intestinal mucosa during HIV-1 infection has not been well characterized.
This study examined the frequency, phenotype, and functional status of T cell populations in the gut-associated lymphoid tissue and peripheral blood of virologically suppressed HIV-1-infected patients on therapy, focusing on the Th1, Th17, Tc1, and Tc17 cell subsets.
We found a persistent immune cell activation (CD38 and HLADR expression) into the GALT despite the higher levels of Th17 and Tc17 in respect to peripheral blood.
An upregulation of type I IFN response in GALT compared to the peripheral blood compartment was also recorded.
Furthermore, IFN-α/β levels were negatively related to the frequencies of Th1 naïve cells and Tc1 cell subsets (naïve, central memory, and effector memory) in the GALT.
In contrast, no relationships between type I IFN response and Th1 or Tc1 cell subsets in peripheral blood compartment and between IFN-α/β and Th17/Tc17 in both GALT and peripheral blood district were recorded.
These data indicate that prolonged antiretroviral treatment improves GALT immune function despite the persistence of immune activation and type I IFN response in chronic HIV-1 positive patients.
American Psychological Association (APA)
D'Ettorre, Gabriella& Ceccarelli, Giancarlo& Andreotti, Mauro& Selvaggi, Carla& Giustini, Noemi& Serafino, Sara…[et al.]. 2015. Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072304
Modern Language Association (MLA)
D'Ettorre, Gabriella…[et al.]. Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072304
American Medical Association (AMA)
D'Ettorre, Gabriella& Ceccarelli, Giancarlo& Andreotti, Mauro& Selvaggi, Carla& Giustini, Noemi& Serafino, Sara…[et al.]. Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072304
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072304