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Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction
Joint Authors
Hector, Andreas
Eickelberg, O.
Mall, Marcus
Marcos, Veronica
Zhou-Suckow, Zhe
Önder Yildirim, Ali
Bohla, Alexander
Vitkov, Ljubomir
Krautgartner, Wolf Dietrich
Stoiber, Walter
Hartl, Dominik
Griese, Matthias
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chronic obstructive lung disease determines morbidity and mortality of patients with cystic fibrosis (CF).
CF airways are characterized by a nonresolving neutrophilic inflammation.
After pathogen contact or prolonged activation, neutrophils release DNA fibres decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs).
NETs have been described to act in a beneficial way for innate host defense by bactericidal, fungicidal, and virucidal actions.
On the other hand, excessive NET formation has been linked to the pathogenesis of autoinflammatory and autoimmune disease conditions.
We quantified free DNA structures characteristic of NETs in airway fluids of CF patients and a mouse model with CF-like lung disease.
Free DNA levels correlated with airflow obstruction, fungal colonization, and CXC chemokine levels in CF patients and CF-like mice.
When viewed in combination, our results demonstrate that neutrophilic inflammation in CF airways is associated with abundant free DNA characteristic for NETosis, and suggest that free DNA may be implicated in lung function decline in patients with CF.
American Psychological Association (APA)
Marcos, Veronica& Zhou-Suckow, Zhe& Önder Yildirim, Ali& Bohla, Alexander& Hector, Andreas& Vitkov, Ljubomir…[et al.]. 2015. Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072309
Modern Language Association (MLA)
Marcos, Veronica…[et al.]. Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072309
American Medical Association (AMA)
Marcos, Veronica& Zhou-Suckow, Zhe& Önder Yildirim, Ali& Bohla, Alexander& Hector, Andreas& Vitkov, Ljubomir…[et al.]. Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072309
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072309