Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology
Author
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a “firebreak” to slow transmission.
A promising avenue to increase current therapeutic efficacy may be through incorporation of adjunct components that slow or stop development of aggressive destructive pulmonary pathology.
Lactoferrin, an iron-binding glycoprotein found in mucosal secretions and granules of neutrophils, is just such a potential adjunct therapeutic agent.
The focus of this review is to explore the utility of lactoferrin to serve as a therapeutic tool to investigate “disruption” of the mycobacterial granuloma.
Proposed concepts for mechanisms underlying lactoferrin efficacy to control immunopathology are supported by data generated based on in vivo models using nonpathogenic trehalose 6,6′-dimycolate (TDM, cord factor).
American Psychological Association (APA)
Actor, Jeffrey K.. 2015. Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072311
Modern Language Association (MLA)
Actor, Jeffrey K.. Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072311
American Medical Association (AMA)
Actor, Jeffrey K.. Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072311