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Tumor-Induced Local and Systemic Impact on Blood Vessel Function
Joint Authors
Cedervall, Jessica
Dimberg, A.
Olsson, A-K.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Endothelial dysfunction plays a role in several processes that contribute to cancer-associated mortality.
The vessel wall serves as a barrier for metastatic tumor cells, and the integrity and activation status of the endothelium serves as an important defense mechanism against metastasis.
In addition, leukocytes, such as cytotoxic T-cells, have to travel across the vessel wall to enter the tumor tissue where they contribute to killing of cancer cells.
Tumor cells can alter the characteristics of the endothelium by recruitment of leukocytes such as neutrophils and macrophages, which further stimulate inflammation and promote tumorigenesis.
Recent findings also suggest that leukocyte-mediated effects on vascular function are not limited to the primary tumor or tissues that represent metastatic sites.
Peripheral organs, such as kidney and heart, also display impaired vascular function in tumor-bearing individuals, potentially contributing to organ failure.
Here, we discuss how vascular function is altered in malignant tissue and distant organs in individuals with cancer and how leukocytes function as potent mediators of these tumor-induced effects.
American Psychological Association (APA)
Cedervall, Jessica& Dimberg, A.& Olsson, A-K.. 2015. Tumor-Induced Local and Systemic Impact on Blood Vessel Function. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072318
Modern Language Association (MLA)
Cedervall, Jessica…[et al.]. Tumor-Induced Local and Systemic Impact on Blood Vessel Function. Mediators of Inflammation No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1072318
American Medical Association (AMA)
Cedervall, Jessica& Dimberg, A.& Olsson, A-K.. Tumor-Induced Local and Systemic Impact on Blood Vessel Function. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1072318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072318